Attention

According to the latest research in our Center, the concentration of manganese (Mn) in the serum is significantly correlated with the life expectancy of women with cancer.

Manganese is an essential nutrient involved in the proper functioning of the immune system, regulation of blood sugar levels and cellular energy, reproduction, digestion, bone growth, blood clotting, and homeostasis, as well as defense against reactive oxygen species. The functions performed by manganese metalloproteins include oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. Mn acts as a cofactor for various enzymes, including arginase, glutamine synthetase (GS), pyruvate carboxylase, and manganese superoxide dismutase (Mn-SOD). Mn tends to accumulate in the liver, pancreas, bones, and brain.

Mn absorption depends, among other things, on gender and ferritin content (J. W. Finley, P.E. Johnson, L.K. Johnson Sex affects manganese absorption and retention by humans from a diet adequate in manganese Am Clin Nutr 1994, J.W. Finley Manganese absorption and retention by young women is associated with serum ferritin concentration Am J Clin Nutr. 1999).

Products low in manganese

Products with the lowest manganese content include, among others, corn flakes, cream, kefir, yogurt, milk, yellow cheese, eggs, meat, fish, edible fats, and fruits.

Below is the list of products with data about manganese content in products based on the book "Food Composition Tables" by H. Kunachowicz et al., PZWL, 2nd edition revised 2017.

In the PDF file, you will find a study divided into product categories.

Products with high manganese content

The richest sources of manganese are products such as wheat, rye, hazelnuts, walnuts, poppy seeds, sunflower seeds, cocoa, peas, and white beans.

Below is the list of products with data about manganese content in products based on the book "Food Composition Tables" by H. Kunachowicz et al., PZWL, 2nd edition revised 2017.

In the PDF file, you will find a study divided into product categories.

ATTENTION! It should be noted that the above norms are based on scientific research but may be subject to change as further studies are conducted. Detailed dietary recommendations allowing for optimal modification of manganese in serum are currently being developed.

developed by:
mgr Paulina Waszczuk
mgr Róża Derkacz
prof. dr. hab. n. med. Jan Lubiński

According to current data observed also in studies conducted in our center, copper belongs to the elements of very important significance in the prevention and early detection of cancers. It seems that copper plays the most significant role in the course of processes related to the survival of patients affected by malignant tumors. In patients with malignant tumors, the risk of death within 5 and 10 years from diagnosis increases several to several dozen times with high copper levels in the blood. This risk is increased in all malignant tumors examined by us (breast cancer, prostate cancer, malignant melanoma, laryngeal cancer). It seems justified for patients with malignant tumors to preferentially consume products with low copper content.

Below is the list of products with data about copper content in products based on the book "Food Composition Tables" by H. Kunachowicz et al., PZWL, 2nd edition revised 2017.

Products low in copper content

Products with the lowest copper content include, among others, drinks (e.g. tea, lemonade), various types of oils (e.g. rapeseed, sunflower), and dairy products.

Below is the list of products with data about copper content in products based on the book "Food Composition Tables" by H. Kunachowicz et al., PZWL, 2nd edition revised 2017.

In the PDF file, you will find a study divided into product categories.

Products with high copper content

The richest sources of copper are products such as wheat, meat (including fish), offal, vegetables, and fruit.

Below is the list of products with data about copper content in products based on the book "Food Composition Tables" by H. Kunachowicz et al., PZWL, 2nd edition revised 2017.

In the PDF file, you will find a study divided into product categories.

Cadmium is an element that is toxic to our bodies. According to the International Agency for Research on Cancer (IARC), cadmium and its compounds have been defined as absolute human carcinogens - group 1. Nevertheless, there are exceptions in which it is necessary to maintain this element at a minimum level. The adverse effects of cadmium and its compounds may lead to kidney and cardiovascular diseases, hypertension, anemia, liver damage, immune system disorders, iron, copper, and zinc deficiencies, as well as the development of cancer. Our research on the Polish population showed a relationship between the concentration of cadmium in whole blood and the risk of developing malignant tumors in women and men.

Reduction

The effectiveness of modifying cadmium concentration in blood is poorly known. Certainly, people who smoke cigarettes should quit smoking - smoking significantly increases the concentration of cadmium.

Modifying your diet can also lower cadmium levels. Products containing higher concentrations of this element include seafood, offal, cereals, oilseeds, soybeans, cocoa, and vegetables (mainly spinach, potatoes, and dried mushrooms). The absorption of cadmium from food may also be increased with deficiencies of other elements, e.g. zinc.

Increase

Consider introducing products with a higher cadmium content into your diet. Products containing higher concentrations of this element include seafood, offal, cereals, oilseeds, soybeans, cocoa, and vegetables (mainly spinach, potatoes, and dried mushrooms).

Environmental lead (Pb) contamination is an ongoing problem for developing societies. The toxic effect of lead mainly concerns its effect on the hematopoietic system (Johnson, F.M. The Genetic Effects of Environmental Lead. Mutat Res 1998), peripheral and central nervous system (Marchetti, C. Molecular Targets of Lead in Brain Neurotoxicity. Neurotox Res 2003) and the digestive tract (Tomczyk, J.; Lewczuk, E.; Abdrzejak, R. Ostre Zatrucia Organicznymi Związkami Ołowiu.; Medycyna Pracy, 1999). Due to the ubiquity of lead, virtually every person is exposed to contact with this element. Lead toxicity leads, among other things, to changes in the activity of many enzymes and disturbances in the functions of free and structural proteins in the cell (Cellular Mechanisms of Lead Neurotoxicity). Many studies suggest that an important molecular mechanism of lead toxicity is its participation in the formation of free oxygen radicals, which play a large role in the formation of intracellular damage and the pathogenesis of many diseases, including malignant tumors (Nersesyan, A.; Kundi, M.; Waldherr, M.; Setayesh, T.; Mišík, M.; Wultsch, G.; Filipic, M.; Mazzaron Barcelos, G.R.; Knasmueller, S. Results of Micronucleus Assays with Individuals Who Are Occupationally and Environmentally Exposed to Mercury, Lead and Cadmium. Mutat Res 2016). According to the IARC classification of carcinogens, lead and its compounds belong to groups 2a and 2b, i.e. potentially carcinogenic (List of Classifications – IARC Monographs on the Identification of Carcinogenic Hazards to Humans).

Reduction

Studies carried out in our Center have shown that the concentration of lead in the blood is effectively reduced with DMSA supplementation (dose: 10 mg/kg). In the study protocol, after 1 month of supplementation, all participants were detoxified from lead, but after a few weeks, lead concentrations increased again. A detailed description of the protocol can be found here here.

Data on lead content in food products is summarized below, based on the following scientific publications:

• Liang G, Gong W, Li B, Zuo J, Pan L, Liu X. Analysis of Heavy Metals in Foodstuffs and an Assessment of the Health Risks to the General Public via Consumption in Beijing, China. Int J Environ Res Public Health. 2019;16(6):909. Published 2019 Mar 13.
• Jitaru P, Ingenbleek L, Marchond N, et al. Occurrence of 30 trace elements in foods from a multi-centre Sub-Saharan Africa Total Diet Study: Focus on Al, As, Cd, Hg, and Pb. Environ Int. 2019;133(Pt B):105197.
• Rusin, M., Domagalska, J., Rogala, D. et al.Concentration of cadmium and lead in vegetables and fruits. Sci Rep 11, 11913 (2021).
• Scientific Report Of EFSA- Lead dietary exposure in the European population, 2012

Products low in lead

Products with the lowest lead content include, among others, Brussels sprouts, animal milk, sweet potatoes, eggs, pasta and mango.

Attention! Please remember that the concentration of lead in dried products may be up to 8 times higher than in fresh ones.

Products with high lead content

The products with the highest lead content include, among others, fish and seafood, cabbage, and carrots.

*Liquid foods are taken in larger quantities than solid foods; they are also usually better absorbed by the body, which is why we classify them as products with high lead concentrations.

Attention It should be noted that the dietary suggestions provided are the only options to consider. To receive personalized dietary recommendations, including any restrictions (e.g., intolerances, allergies), and patient preferences, it is necessary to consult a dietitian.

According to the review of scientific literature as of March 20, 2021, we consider the article to be the most complete and in-depth: Shiqian Hu and Margaret P. Rayman,µ Multiple Nutritional Factors and the Risk of Hashimoto’s Thyroiditis (Thyroid Vol. 27, Number 5, 2017; Mary Ann Liebert Inc. DOI: 10.1089/thy.2016.0635).

Most studies show a reduced incidence of thyroid diseases in people taking selenium supplementation due to an increase in the level of antithyroid antibodies, especially anti-TPO. Supplementation at a dose of approximately 200 µg of selenium per day for a period of 6-12 months in most people results in a reduction in the level of antibodies (P. Zagrodzki, J. Kowalczyk, Znaczenie selenu w leczeniu choroby Hashimoto; Postępy Hig Med Dosw (online), 2014; 68: 1129-1137, e-ISSN 1732-2693); (R. Krysiak, K.Kowalcze, B. Okopień, Hyperprolactinemia attenuates the inhibitory effect of vitamin D/selenomethionine combination therapy on thyroid women with Hashimoto’s thyroiditis: A pilot study. J CLin Pharm Ther. 2020;451334-1341). A similar correlation was also observed in the study by Kryczyk-Kozioł Jadwiga et al. (Kryczyk-Kozioł J., Zagrodzki P., et al, Positive effects of selenium supplementation in women with newly diagnosed Hashimoto’s thyroiditis in an area with low selenium status. Int J Clin Pract. 2021).

Current data from the literature indicate the advisability of considering selenium supplementation in people with Hashimoto's disease, although most authors agree with the opinion that there is still no current data to consider such treatment as a standard.

Due to our many years of experience, we believe that the expectations regarding bioavailability are very well met by the Sel-BRCA1 preparation we have developed, available on our website read-gene.com

If you have any problems obtaining recommendations, please contact: eksperci@sel-brca1.pl

Please read our procedure for people diagnosed with Hashimoto's disease - click here